Exploring cellular aging and health
Fisetin is a naturally occurring flavonoid found in many fruits and vegetables, like strawberries and apples. Known for its vibrant yellow pigment, fisetin has piqued interest for its potential health benefits, particularly in the realms of aging and brain health.
About Fisetin
Origins and Structure
Fisetin is a polyphenolic compound found in various plants. It’s closely related to quercetin and kaempferol. Structurally, it boasts a robust configuration with four hydroxyl groups, lending it strong antioxidant properties.
Cellular Impact
In laboratory settings, fisetin shows promise as a senolytic agent, meaning it may help clear out aging cells. It works by downregulating certain proteins that usually prevent cell death, thus nudging old cells toward their natural end.
Neuroprotective Potential
Fisetin can cross the blood-brain barrier, which is a significant feat for any compound. Once inside, it may help reduce inflammation and combat the buildup of harmful proteins associated with brain aging.
Metabolic Effects
Animal studies suggest that fisetin may influence metabolism by activating proteins that help regulate energy and glucose levels. This could potentially support healthier metabolic activity.
Challenges and Delivery
Despite its potential, fisetin faces hurdles like low solubility and rapid metabolism. Researchers are experimenting with different formulations to improve its effectiveness.
Related Products
Formulated With
Learn about other ingredients that Fisetin is used alongside throughout the LVLUP range.
Detailed Information
Antioxidant Mechanisms
Fisetin exhibits strong radical-scavenging abilities due to its hydroxyl groups. It contributes to maintaining cellular redox balance by neutralizing reactive oxygen species, which are often culprits in cellular aging and disease.
Senolytic Activity
Preclinical studies highlight fisetin’s ability to selectively induce apoptosis in senescent cells. By downregulating anti-apoptotic proteins in these cells, it helps promote clearance of dysfunctional cells, which could ameliorate age-related tissue damage.
Neuroprotective Actions
Fisetin’s ability to cross the blood-brain barrier enables it to engage multiple neuroprotective pathways. It reduces pro-inflammatory cytokines like IL-6 and TNF-alpha and inhibits the aggregation of amyloid-beta, potentially mitigating neurodegenerative processes.
Metabolic Modulation
Fisetin has been observed to activate AMP-activated protein kinase (AMPK), an important regulator of cellular energy homeostasis. This activation can lead to reduced gluconeogenesis in the liver and improved insulin sensitivity, suggesting potential benefits for metabolic disorders.
Solubility and Bioavailability
Challenges in fisetin’s application include its low aqueous solubility and rapid hepatic metabolism. Various strategies, including encapsulation and formulation adjustments, are being researched to enhance its bioavailability and therapeutic impact.
