Supports memory and focus.
Huperzine A is derived from Chinese club moss and is known for its potential to support memory, focus, and cognitive clarity. It’s a favorite in cognitive support supplements, highlighting its plant-based origins and targeted effects.
About Huperzine A
What is Huperzine A?
Huperzine A is a plant-derived compound extracted from Huperzia serrata, commonly known as Chinese club moss. It’s prized for its role in supporting cognitive functions, particularly memory and focus.
How It Works
Huperzine A acts by modulating the enzyme acetylcholinesterase. This enzyme breaks down acetylcholine, a neurotransmitter crucial for learning and memory. By inhibiting this enzyme, Huperzine A helps maintain higher acetylcholine levels, enhancing cognitive processes.
Common Uses
You’ll find Huperzine A in nootropic stacks aimed at improving mental clarity, learning speed, and energy. It pairs well with ingredients like Bacopa and adaptogenic herbs, offering a comprehensive approach to brain health.
Formulations and Stability
Capsules and tablets are the preferred forms due to stability. The “1%” labeling ensures each serving delivers a consistent and standardized amount.
Target Audience
Students, professionals, and adults seeking to maintain mental sharpness under pressure often turn to Huperzine A. It’s frequently included in blends targeting mental alertness and memory support.
Related Products
Formulated With
Learn about other ingredients that Huperzine A is used alongside throughout the LVLUP range.
Detailed Information
Mechanism of Action
Huperzine A, known chemically as [(5R)-5-amino-11-ethylidene-5,6-dihydro-4H-pyrido[2,1-b][1,3]benzoxazin-9(11H)-one], is a reversible inhibitor of acetylcholinesterase (AChE). It binds to the enzyme’s active site through hydrogen bonding and hydrophobic interactions, preventing acetylcholine breakdown and enhancing neurotransmission, especially in memory-related brain regions.
Pharmacokinetics
With favorable oral bioavailability due to its lipid solubility, Huperzine A reaches peak plasma levels within 60–80 minutes post-ingestion. Its elimination half-life is 4–6 hours, influenced by individual metabolic differences. It effectively crosses the blood-brain barrier, ensuring central nervous system activity.
Additional Mechanisms
Besides acetylcholinesterase inhibition, Huperzine A may offer neuroprotection by opposing NMDA receptor-mediated excitotoxicity and providing antioxidative effects. Its structure allows free radical scavenging, contributing to its neuroprotective profile.
Synergistic Combinations
Combining Huperzine A with Bacopa monnieri or phosphatidylserine may enhance cognitive benefits. These combinations can support neuroplasticity and sustain BDNF expression, particularly during cognitive stress.
