Supports liver health and detoxification
Globe Artichoke Leaf Extract is derived from the leaves of the artichoke plant, a staple in Mediterranean diets for centuries. This extract, concentrated at a 15:1 ratio, provides potent levels of cynarin and chlorogenic acids. It’s widely used for liver support, aiding digestion, and helping detox processes.
About Globe Artichoke Leaf Extract
Traditional Use and Modern Application
Globe Artichoke Leaf has been a part of Mediterranean culture for ages, primarily for its digestive and liver-supporting properties. Today, it’s a go-to in supplements aimed at enhancing the liver’s ability to process toxins, metabolize fats, and maintain digestive health after heavy meals or exposure to environmental elements.
Mechanism of Action
This extract is known to boost bile production, functioning as the body’s natural emulsifier to break down fats and absorb nutrients efficiently. Alongside, it supports the liver’s detox processes, particularly Phase II conjugation, ensuring waste products are effectively cleared from the body.
Anti-inflammatory and Regenerative Properties
Within the liver, cynarin showcases anti-inflammatory effects. It’s often utilized during stress, poor diet phases, or toxin exposure. Cynarin also aids in liver tissue regeneration and supports cholesterol metabolism by modulating bile synthesis and liver enzymes.
Combinations and Uses
Typically, globe artichoke leaf extract is combined with botanicals like milk thistle or turmeric for comprehensive gut-liver health. It’s popular among those managing occasional bloating or aiming for cholesterol balance.
Related Products
Formulated With
Learn about other ingredients that Globe Artichoke Leaf Extract is used alongside throughout the LVLUP range.
Detailed Information
Active Compounds and Their Roles
Standardized Globe Artichoke Leaf Extract at a 15:1 concentration ensures high levels of caffeoylquinic acids, mainly cynarin and chlorogenic acid derivatives. Cynarin plays a role in modulating hepatic FXR signaling and enhances bile acid synthesis, impacting cholesterol homeostasis for better lipid processing.
Inflammation and Detoxification
The extract’s anti-inflammatory properties stem from Nrf2 pathway activation, leading to increased production of Phase II detox enzymes like glutathione S-transferases. This action supports oxidative stress neutralization and toxin elimination. It also affects hepatic PPAR pathways, linked to fatty acid oxidation and triglyceride metabolism.
Liver Regeneration and Bioavailability
Hepatocyte growth factor upregulation through these phytochemicals aids liver regeneration, especially post-toxin exposure or dietary stress. Co-formulation with phospholipids or absorption enhancers like piperine can further optimize bioavailability in complex supplements.
