Supports memory and neural resilience
Dihydroxyflavone Combination blends plant-based flavonoids with two hydroxyl groups on their structures. These molecules are known for their potential in brain support, playing a role in protecting nerve cells and supporting memory, learning, and focus.
About Dihydroxyflavone
What Sets Dihydroxyflavones Apart
Dihydroxyflavones are part of the larger family of flavonoids, those colorful plant molecules found in berries, tea, and citrus. The ‘dihydroxy’ part means each molecule carries two -OH groups, altering how the body can utilize them. Researchers focus on molecules like 7,8-dihydroxyflavone for their interaction with BDNF (brain-derived neurotrophic factor), which acts as a fertilizer for your neurons. This interaction may support memory preservation and focus, especially in challenging situations.
Why Blend Dihydroxyflavones?
A combination of different dihydroxyflavones offers a broader spectrum of activity than any single molecule could provide. In supplement formulas, they are often paired with adaptogens (stress buffers) or amino acids (neurotransmitter building blocks). This multi-faceted approach supports the complex pathways involved in memory retention, mental clarity, and nerve resilience, particularly during stressful periods or as the brain ages.
Who Might Use Them?
Dihydroxyflavone combinations are found in products targeting adults interested in supporting brain health, maintaining mental sharpness during busy times, or preserving cognitive flexibility with age. Biohackers might seek these to overcome mental blocks or maintain focus during intense work cycles. They’re also used by those aiming for long-term brain health.
Supplement Routine Integration
Typically, dihydroxyflavone combos appear in capsules or powders, often alongside ingredients like ginkgo for circulation, Rhodiola for stress, and B vitamins for nerve health. The goal is to build a robust foundation for the nervous system by layering supportive ingredients.
Related Products
Formulated With
Learn about other ingredients that Dihydroxyflavone is used alongside throughout the LVLUP range.
Detailed Information
Structural Characteristics
Dihydroxyflavones are a subset of flavonoids with two hydroxyl groups on the phenolic rings, typically on the A- and/or C-rings. The key molecule, 7,8-dihydroxyflavone (7,8-DHF), binds to TrkB receptors and mimics BDNF signaling. This interaction modulates PI3K/Akt and MAPK/ERK pathways, enhancing neuronal survival, dendritic complexity, and synaptic plasticity. It also offers resilience to oxidative stress and excitotoxicity.
Synergistic Formulations
In combination formulations, dihydroxyflavones may work synergistically or target complementary pathways like CREB phosphorylation or GSK-3β inhibition. This synergy may boost neuroprotective efficacy under conditions impairing BDNF signaling or increasing neuroinflammation. In preclinical models, chronic use improves hippocampal function, reverses synaptic deficits from β-amyloid oligomers, and reduces pro-inflammatory cytokine expression.
Pharmacokinetics
Dihydroxyflavones generally have moderate lipophilicity, allowing them to cross the blood-brain barrier after oral intake, though bioavailability may be limited by phase II metabolism. Therefore, they are often co-formulated with bioavailability enhancers in supplements targeting neurological health.
