Supports healthy tissue recovery
Ac-SDKP, a small peptide derived from Thymosin Beta-4, is known for its role in supporting tissue recovery. It helps balance inflammation and regulates repair processes, particularly in organs like the heart and liver.
About Thymosin Beta-4 Fragment (Ac-SDKP)
What is Ac-SDKP?
Ac-SDKP, or N-acetyl-seryl-aspartyl-lysyl-proline, is a naturally occurring fragment of the Thymosin Beta-4 protein. It has gained attention for its involvement in the body’s healing responses, particularly regarding organs such as the heart, liver, and kidneys. Researchers are interested in how Ac-SDKP influences tissue resilience by steering inflammation and fibrosis in a measured way.
Uses in Supplement Formulas
Within supplements, Ac-SDKP pairs well with other peptides or amino acids. Its compact structure aids in absorption, making it suitable for daily maintenance blends or recovery products. You might find Ac-SDKP in products focused on gut lining integrity, liver health, or muscle recovery, often combined with more familiar compounds. While not a staple in everyday supplements, it appears in advanced blends for those looking for extra support in recovery.
Who Uses Ac-SDKP?
Ac-SDKP attracts athletes, biohackers, and individuals recovering from physical or medical stress. If you’re interested in tissue health trends or research into fibrosis modulation and anti-inflammatory strategies, this peptide is noteworthy.
Related Products
Formulated With
Learn about other ingredients that Thymosin Beta-4 Fragment (Ac-SDKP) is used alongside throughout the LVLUP range.
Detailed Information
Mechanism of Action
Ac-SDKP is a tetrapeptide, released from Thymosin Beta-4 via prolyl oligopeptidase activity. It modulates inflammatory responses and suppresses pathological fibrosis by inhibiting the proliferation and differentiation of fibroblasts and myofibroblasts. This occurs mainly through interference with the TGF-beta/Smad signaling pathways. In preclinical models, elevated Ac-SDKP levels correlate with reduced collagen deposition and decreased expression of pro-fibrotic markers, alongside improved functional outcomes.
Anti-Inflammatory Properties
Ac-SDKP reduces monocyte/macrophage infiltration during tissue repair’s acute phase. It helps maintain endothelial homeostasis by promoting angiogenesis while reducing excessive vascular permeability. Pharmacokinetics indicate rapid systemic distribution post-administration, with renal clearance predominating. Oral bioavailability is limited but can be enhanced through molecular delivery systems or co-formulation with absorption-promoting agents.
