Helps break down dietary histamine
DAO2 is a highly active source of diamine oxidase enzyme extracted from pig kidneys. It supports the breakdown of food-derived histamine within the digestive tract - particularly useful when natural enzyme levels are low due to genetic or environmental factors.
About DAO2
Understanding Histamine Breakdown
Understanding how your body handles dietary histamine comes down to diamine oxidase activity in the gut wall. Pig kidney extract offers a concentrated supply of this enzyme (called DAO), which helps neutralize excess histamine from foods like wine, cheese, cured meats, and fermented products before they cause discomfort.
Addressing Histamine Intolerance
People prone to headaches after certain foods or unexplained digestive woes may be experiencing mild histamine intolerance tied to low natural DAO production. DAO2 provides targeted enzymatic support when taken shortly before potentially challenging meals.
Combining with Supplements
Supplement blends such as Hista-Resist combine DAO2 with botanicals supporting mast cell stability – addressing both immediate reactions and long-term digestive resilience. Animal sources like porcine kidney are favored for their high active enzyme content compared to plant options.
Smoother Digestion
Combining DAO2 with probiotics or other gut-focused nutrients is common in formulations aimed at promoting smoother digestion under real-world eating conditions. You’ll find these blends most helpful around holidays or social gatherings when meal choices are less predictable.
Related Products
Formulated With
Learn about other ingredients that DAO2 is used alongside throughout the LVLUP range.
Detailed Information
Catalytic Efficiency of DAO
Porcine kidney-derived diamine oxidase (EC 1.4.3.22) demonstrates robust catalytic efficiency against foodborne biogenic amines – especially histamine – within intestinal villi following oral ingestion. Due to superior enzyme concentration in renal tissue versus botanicals, porcine extract enables higher oral dosing per capsule.
Bioavailability and Effectiveness
Oral bioavailability is enhanced through enterically coated delivery vehicles that protect enzymatic structure during gastric transit; maximal effect is realized when administered immediately prior to ingestion of high-histamine meals.
Clinical Utility
Clinical utility targets individuals with genetic reductions in AOC1 expression or pharmacologically acquired downregulation/inhibition of endogenous human intestinal DAO production. Beyond direct substrate hydrolysis (histamine breakdown), porcine kidney-derived DAO exerts secondary effects through limiting mast cell-mediated inflammatory mediator release within the gastrointestinal mucosa; this dual action supports reduced symptom severity during exposure episodes.
Stacking and Synergy
Stacking with co-factors such as quercetin may further stabilize mast cells via downregulation of IgE-mediated activation pathways. Advanced multi-ingredient supplements combine exogenous porcine-derived DAO with selected prebiotics/probiotics for synergistic modulation of epithelial tight junction integrity and reduced paracellular translocation of luminal antigens associated with food sensitivities.
