Supports liver health and recovery
Dihydromyricetin (DHM) is a plant-based flavonoid with roots in centuries-old East Asian traditions. It's often used for liver and brain support, especially post-social drinking or for maintaining daily liver health. You'll find DHM in targeted supplements and complex blends, favored by those seeking brain clarity and liver resilience.
About DHM
Origins and Traditional Use
Dihydromyricetin, commonly known as DHM, is derived from the Japanese raisin tree. It’s been a staple in East Asian traditional remedies, prized for its potential to support liver function and cognitive clarity.
Mechanism and Benefits
DHM is celebrated for its antioxidant properties, particularly in managing alcohol’s effects. It helps accelerate the breakdown of ethanol and its byproduct, acetaldehyde, which can contribute to hangover symptoms and liver stress.
Liver Protection
DHM acts as a scavenger of free radicals in liver cells, shielding against oxidative stress. It also reduces inflammation by inhibiting pathways like TNF-Alpha and interleukin-6, helping maintain a balanced liver environment.
Fibrosis Prevention
Regular use of DHM may slow hepatic stellate cell activation, potentially preventing fibrosis and cirrhosis, conditions that can limit liver function over time.
Biohacking and Synergies
Biohackers often pair DHM with other antioxidants, like milk thistle or N-acetylcysteine (NAC), or use it in anti-aging routines to combat oxidative damage. It’s available as a standalone supplement or in complex formulations for comprehensive liver support.
Related Products
Formulated With
Learn about other ingredients that DHM is used alongside throughout the LVLUP range.
Detailed Information
Chemical Structure and Enzymatic Impact
Dihydromyricetin (C15H12O8) is a flavanonol with hydroxyl groups that provide high redox potential, enabling rapid quenching of reactive oxygen species during ethanol metabolism. Studies show improved ethanol and acetaldehyde clearance due to upregulation of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH).
Anti-inflammatory and Cellular Protection
DHM reduces hepatic pro-inflammatory cytokines, particularly by downregulating TNF-Alpha and interleukin-6 through NF-ÎşB signaling modulation. It also promotes Nrf2 activation, enhancing cytoprotective gene expression in hepatocytes. DHM disrupts fibrogenesis by impeding hepatic stellate cell activation via TGF-beta receptor blockade.
Neurological Modulation
In central nervous system studies, DHM antagonizes GABA_A receptor subunits involved in ethanol-induced inhibitory potentiation, stabilizing neurotransmitter activity without receptor desensitization.
Bioavailability
Human pharmacokinetic profiles indicate rapid first-pass metabolism mainly via glucuronide conjugation. Repeated administration shows favorable safety and minimal tissue accumulation at standard dosages.
