Supports appetite control and focus.
Tesofensine is renowned for its effects on appetite and body weight. Originally developed for neurodegenerative diseases, it was found to impact weight management significantly. This makes it popular in products targeting weight control and mental clarity.
About Tesofensine
How it Works
Tesofensine belongs to the class of serotonin-noradrenaline-dopamine reuptake inhibitors. In simple terms, it helps keep three neurotransmitters—serotonin, noradrenaline, and dopamine—active longer in the brain. These play a crucial role in how you feel hunger and focus your attention.
Unexpected Origins
Initially explored as a treatment for conditions like Parkinson’s, researchers observed a noticeable weight loss in participants. Its most significant impact seems to be a reduced urge to eat, often leading to less snacking or feeling full faster during meals.
Benefits Beyond Appetite
By increasing dopamine and noradrenaline levels moderately, Tesofensine can support alertness and mental energy. However, in most supplement blends, its primary role is appetite control.
Real-world Applications
Unlike stimulants like caffeine, Tesofensine quietly aids in achieving a sense of satisfaction after eating and can help maintain motivation for healthy habits. It’s often included with adaptogens or amino acids to provide balanced support.
Who Can Benefit?
For those aiming at weight goals or wishing to avoid constant cravings, Tesofensine could be beneficial. It’s popular among individuals interested in metabolic optimization and those focused on brain-body connections.
Related Products
Formulated With
Learn about other ingredients that Tesofensine is used alongside throughout the LVLUP range.
Detailed Information
Mechanism of Action
Tesofensine acts as a triple monoamine reuptake inhibitor by selectively blocking the presynaptic reuptake of serotonin (5-HT), noradrenaline (NE), and dopamine (DA) within central nervous system pathways involved in appetite regulation and reward processing. By elevating extracellular concentrations of these neurotransmitters in hypothalamic nuclei, it disrupts neurochemical signaling associated with caloric intake and satiety cues.
Preclinical and Clinical Insights
Preclinical studies show significant reductions in feeding behavior attributed primarily to dopaminergic modulation within mesolimbic pathways. Human trials demonstrate decreased food intake and BMI across dosing schedules compared to placebo.
Cognitive and Bioavailability Factors
Cognitive testing reveals mild improvements in reaction time and executive function, secondary to metabolic outcomes. Tesofensine exhibits oral bioavailability above 10 percent, with hepatic metabolism via CYP3A4/5 isoenzymes.
Formulation Strategies
Supplement formulations typically use microgram-precision titration protocols. Use in blends may include co-formulants like L-carnitine or Rhodiola rosea to augment satiety signaling and mitigate tachyphylaxis risk.
