Supports cognitive and gut health
Luteolin is a natural flavonoid found in plants like celery, parsley, and chamomile. Known for its potential benefits on brain, gut, and immune health, it's often used in supplements aimed at calming the digestive system and balancing histamine levels.
About Luteolin
Getting to Know Luteolin
Every time you sprinkle parsley on your meal or sip chamomile tea, you’re consuming luteolin. This flavonoid acts as a defense mechanism in plants, and in humans, it’s catching the eye of researchers for its calming effects on the mind and body. Luteolin’s ability to cross the blood-brain barrier makes it a popular choice in cognitive supplements. It’s often combined with other natural compounds to promote clear thinking and calmness.
The Role in Gut and Immune Health
Luteolin also plays a role in the gut microbiome, where it interacts with bacteria crucial for digestion and immune health. It’s known for helping regulate mast cells, which are involved in histamine release. This can be beneficial if you’re dealing with histamine reactions or seeking to manage inflammation during allergy season.
Combination and Integration
Luteolin shines when paired with other flavonoids like quercetin and rutin, and digestive enzymes such as bromelain. These combinations mimic the way plants function in nature, using a network of compounds to enhance each other’s effects. Together, they support digestion, manage histamine levels, and maintain gut health.
In Digestive and Histamine Support Blends
In products like Hista-Resist, luteolin works alongside quercetin, rutin, and bromelain. Luteolin helps stabilize mast cells, while quercetin boosts its effects. Rutin supports capillary strength, and bromelain aids protein digestion. This blend supports smoother digestion and helps manage histamine-related issues.
Related Products
Formulated With
Learn about other ingredients that Luteolin is used alongside throughout the LVLUP range.
Detailed Information
Scientific Insights into Luteolin
Luteolin (3′,4′,5,7-tetrahydroxyflavone) is known for its polyphenolic properties due to its hydroxylation pattern. It crosses lipid bilayers, interacting with membrane receptors and intracellular targets. Luteolin modulates NF-ÎşB activation, impacting neuroinflammation and microglial phenotype polarization between pro-inflammatory M1 and anti-inflammatory M2 profiles.
Mechanisms and Interactions
Cell culture studies show luteolin suppresses antigen-stimulated mast cell degranulation by modulating calcium influx. It reduces IL-6 and TNF-alpha expression while increasing IL-10. These effects contribute to neuroprotection by enhancing endogenous antioxidant systems like SOD1, SOD2, and catalase in neurons exposed to oxidative stress.
Microbiota and Biotransformation
Luteolin undergoes microbiota-driven transformations into glucuronide and sulfate conjugates, with specific microbial taxa involved in its deglycosylation. This process affects its bioefficacy and is a subject of nutrigenomic research.
Combining with Other Compounds
Combining luteolin with quercetin and rutin enhances histamine catabolism by upregulating DAO and HNMT activity. Bromelain improves absorption and reduces local inflammation, optimizing the effects of these flavonoids.
