Supports cellular energy and cognition.
Methylene Blue, once a textile dye, has carved out a niche in both medicine and supplements. It's recognized today for its role in brain and mitochondrial health.
About Methylene Blue
The Origins of Methylene Blue
Methylene Blue’s journey began in the 1800s, initially as a dye. It quickly found its way into medical treatments, particularly for blood disorders like methemoglobinemia. Its modern uses explore cellular functions, especially in mitochondria – the powerhouses of our cells.
How Methylene Blue Works
Acting as an ‘electron cycler’, Methylene Blue aids the mitochondrial electron transport chain. This process is vital for converting food into energy, particularly in energy-demanding tissues like the brain. Its redox capabilities also may help buffer against oxidative stress, a contributor to aging and fatigue.
Supplement Use and Combinations
In supplements, Methylene Blue often pairs with nutrients like Acetyl L-Carnitine and Ubiquinol. These combinations aim to enhance energy production and antioxidant effects. Users report varying experiences, from clearer focus to increased alertness.
Practical Considerations
Methylene Blue turns solutions blue, including capsules and sometimes urine. It remains stable if kept away from sunlight. Typical supplement doses are much lower than medical applications, usually in microgram or milligram amounts.
Who Uses Methylene Blue?
It’s popular among those facing mental or physical fatigue, like athletes, students, and busy professionals. The common goal is boosting cellular energy and resilience against everyday stress.
Related Products
Formulated With
Learn about other ingredients that Methylene Blue is used alongside throughout the LVLUP range.
Detailed Information
Chemical Properties and Mechanism
Known chemically as methylthioninium chloride, Methylene Blue is a phenothiazine derivative with reversible redox activity. In its oxidized form (MB+), it accepts electrons from NADH, acting as an alternative carrier within the mitochondrial electron transport chain (ETC). This action can bypass impaired complexes, reducing ROS production and maintaining ATP output during mitochondrial stress.
Neuroprotective Potential
Methylene Blue has been studied for neuroprotective qualities, such as modulating tau protein aggregation and inhibiting monoamine oxidase (MAO) activity. These effects may vary with dose and context.
Pharmacokinetics and Stability
After oral intake, tissue uptake is rapid, and the plasma half-life is typically brief at standard doses. Its strong chromophoric nature and interactions with redox pathways demand careful control over light exposure and excipient compatibility.
